Source of truth: DISCLAIMER.md in the repository
Medical disclaimer
This page restates DISCLAIMER.md for the static evidence site. If the two ever differ, the repository file wins.
This is a research framework
Project Confluence is a computational research tool for scientific exploration of dynamical-systems approaches to cancer metabolism and closed-loop control. It is:
- not a medical device
- not a clinical decision support system
- not a diagnostic, prognostic, or therapeutic tool
- not approved by the FDA, EMA, or any regulatory body
- not a claim of clinical admissibility, disease eradication, or a treatment path
Connectome controllers (including the optional 166,700-unit sparse net and “protein” / antibody effector channels) are in-silico control signals. They do not synthesize therapeutics, express genes, or constitute a biologic manufacturing or dosing system.
Simulated metrics are research scores on an ODE. Tumor-burden, resistance, fusion-allele, junction-neoantigen, immune-competence, surveillance, antibody-readiness, and therapy-channel numbers are not disease eradication, not clinical benefit, and not a path to a clinical outcome.
Disease-class labels (benign, malignant,
occult, dormant, terminal) are
state-signature modes for computational discrimination. They are not clinical
stage, TNM, or histopathology diagnoses.
RECIST 1.1-like / H-band surrogate (CTCAE-like) / Kaplan–Meier / log-rank / Cox outputs are an in-silico endpoint mapping layer. They are not a clinical trial, not RECIST/CTCAE adjudication, not FDA/EMA readiness, and not a Phase II result.
No medical advice
Nothing in this repository or on this site constitutes medical advice. The computational models are theoretical constructs for research purposes only.
Human oversight required
Any translation toward clinical use must go through:
- Institutional Review Board (IRB) approval
- Pre-clinical validation (in vitro / in vivo)
- Phase I–III clinical trials
- Regulatory approval (FDA 510(k), PMA, or equivalent)
Liability
The authors and contributors assume no liability for outcomes from use or misuse of this software. Users assume responsibility for appropriate use within their regulatory and ethical frameworks.
Contact: Kelechi Ogbonna — @cloudynirvana